GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11190604 | 1 | rs4244338 | chr10:102272802 | SEC31B | chr10:102246403-102289636:- | -0.27 | -8.76 | 3.52E-17 | Palmitoleic acid (16:1n-7) plasma levels |
| THCA | cis | rs4509693 | 1 | rs4244340 | chr10:102499268 | FBXW4 | chr10:103370422-103454743:- | -0.17 | -3.36 | 0.000845 | Alzheimer's disease |
| THCA | cis | rs4245128 | 1 | rs4245128 | chr11:112791983 | NCAM1 | chr11:112831995-113149157:+ | 0.2 | 4.79 | 2.28E-6 | Life satisfaction |
| THCA | cis | rs17122021 | 1 | rs4245180 | chr11:118144512 | AMICA1 | chr11:118064442-118095809:- | 0.09 | 4.04 | 6.14E-5 | Pain |
| THCA | cis | rs17122021 | 1 | rs4245180 | chr11:118144512 | MPZL2 | chr11:118124135-118135009:- | 0.23 | 7.76 | 5.29E-14 | Pain |
| THCA | cis | rs17122021 | 1 | rs4245180 | chr11:118144512 | TREH | chr11:118528942-118550381:- | -0.17 | -3.42 | 0.000689 | Pain |
| THCA | cis | rs7107174 | 1 | rs4245459 | chr11:78065959 | NARS2 | chr11:78147017-78285909:- | -0.39 | -6.92 | 1.49E-11 | Testicular germ cell tumor |
| THCA | cis | rs4246215 | 1 | rs4246215 | chr11:61564299 | FADS2 | chr11:61583728-61634825:+ | 0.42 | 9.4 | 2.3E-19 | Phospholipid levels (plasma);Platelet count;Red blood cell fatty acid levels;Trans fatty acid levels;Inflammatory bowel disease |
| THCA | cis | rs425105 | 1 | rs425105 | chr19:47208481 | FKRP | chr19:47249303-47261832:+ | 0.54 | 7.01 | 8.35E-12 | Type 1 diabetes |
| THCA | cis | rs425105 | 1 | rs425105 | chr19:47208481 | PRKD2 | chr19:47177574-47220384:- | 0.21 | 5.17 | 3.44E-7 | Type 1 diabetes |
| THCA | cis | rs4253772 | 1 | rs4253766 | chr22:46623905 | PKDREJ | chr22:46651561-46659219:- | -0.45 | -5.54 | 4.94E-8 | Cholesterol, total;LDL cholesterol |
| THCA | cis | rs4253772 | 1 | rs4253772 | chr22:46627603 | PKDREJ | chr22:46651561-46659219:- | -0.5 | -5.8 | 1.18E-8 | Cholesterol, total;LDL cholesterol |
| THCA | cis | rs4256922 | 1 | rs4256922 | chr10:52568616 | ASAH2B | chr10:52499696-52514567:+ | -0.26 | -3.97 | 8.19E-5 | Urate levels in lean individuals |
| THCA | cis | rs1552244 | 1 | rs4260416 | chr3:10125283 | C3orf10 | chr3:10157333-10168873:+ | -0.2 | -4.19 | 3.33E-5 | Alzheimer's disease |
| THCA | cis | rs1552244 | 1 | rs4260416 | chr3:10125283 | VHL | chr3:10183319-10193744:+ | -0.19 | -4.37 | 1.54E-5 | Alzheimer's disease |